Researchers are interested in a glomerular disease affecting the kidneys. They have identified the top 25 significantly up-regulated genes. They want you to identify the most important gene ontology (GO) terms related to biological processes (BP) that are over-represented by this gene list. They define important terms as being both significantly enriched and relevant to the disease.
The researchers are expecting a list of terms sorted by importance (most important at the top). Use EnrichR (Enrichr) or clusterProfiler (an R package) to identify the most important enriched BP GO terms.
*Disclaimer: The input data for this question was semi-simulated. While the data was constructed to have results relevant to disease for the purpose of this evaluation, no new insights can be obtained from this dataset.
Go to STEM-Away® Bioinformatics Evaluation - Functional Analysis to get list of genes and submit your answers.
This evaluation is mandatory for placement in Bioinformatics Power Teams. A strong result in the R shiny coding evaluation can be used to qualify if a student lacks the domain expertise needed for this evaluation.
While we encourage all students to attempt the evaluation, this evaluation is not mandatory for placement in Bioinformatics Exploratory Teams.
Your first submission is the one that is graded. If you are not sure about the material, please wait until the corresponding training is held.
Highest level of academic integrity is expected from all members. Subtle changes are made in the test to discourage copying of answers. Submissions include inputs and results.
@anya Anya Greenburg, STEM-Away® Principal Mentor